Intensilk™: Dermohacking cellulite through circular bio-energy

Dermohacking energy from the apple flower to unlock caloric restriction in adipocytes

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1st cosmetic caloric restriction active ingredient for body care

Reduction of receptor-mediated glucose uptake triggers mTOR pathway in adipocytes

Circular bio-energy back to the skin

Coming from locally sourced apple blossom, the ingredient is standardized in phlorizin (antioxidant polyphenol)

Comprehensive metabolic cellulite solution

A multi-omic active ingredient delivering an intensive cellulite treatment with a comprehensive remodeling action on both
adipocyte metabolism and tissue architecture

Groundbreaking longevity for a healthier sculpture

Body sculpting that is visibly effective against cellulite bumps, firmness and skin texture for a smoother, tightened and healthier sculpture

A new era in body well aging

The convergence of longevity-driven lifestyles and heightened consumer demand for wellness has reignited interest in expert-led, clinically-anchored body treatments, meaning bigger opportunities for specialization are appearing in the sector.

Provital, pioneer in cosmetic dermohacking, now harnesses this disruptive vision by bridging longevity science, nature, and body care consumer preferences to push the boundaries of efficacy & sustainability.

Intensilk™ remasters longevity science to dermohack the body for an intensive cellulite treatment with a comprehensive remodeling action on both fat reduction and tissue architecture.

Circular Bio-Energy: where origin and efficacy are intrinsically linked through a continuous metabolic loop

Sourced from the apple flower, antioxidant flavonoids such as phlorizin, in which Intensilk™ is standardized, provide the initial spark, triggering caloric restriction in adipocytes by competing with glucose for binding to glucose-transporters (e.g. SGLTs).

The body then uses excess fat, produced from energy intake, to support cellular functions. In this way, what was once a locally sourced blossom from a family fruit farmer, becomes the key to unlocking the body’s own stored resources.

Mechanism of Action (MoA): Calorie restriction mimetics in adipocytes

Reduction of receptor-mediated glucose uptake in adipocytes.
Metabolic Reprogramming after PI3K–Akt–mTOR signaling pathway is downregulated.
Autophagy-mediated lipid degradation (LIPOPHAGY), Anti-adipogenesis and Lipolysis for Energy recovery + reduction of intra-cellular inflammation.
Remodeling of both hypodermal and dermal extracellular matrix.

In vivo efficacy

Smoothing effect on cellulite dimples: Day 0 (VECTRA-XT 3D images of Vol 3B, before & after +2% Intensilk™)

Smoothing effect on cellulite dimples: Day 56 (VECTRA-XT 3D images of Vol 3B, before & after +2% Intensilk™)

(2% Intensilk) Slow-motion video analysis confirmed an improvement in dynamic tissue tone and bounce-back behavior, resulting in 47 ms less in motion compared to placebo

(Placebo) Slow-motion video analysis confirmed an improvement in dynamic tissue tone and bounce-back behavior, resulting in 47 ms less in motion compared to placebo